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Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes
These micro-clots physically impair capillary blood flow, preventing adequate oxygen and nutrient delivery to skeletal muscles and the brain during exertion
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They associated the early phase with monomers, the middle phase with soluble oligomers, and the final phase with insoluble fibrils
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