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FDA approval also defines exactly who should use the medication

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Regulatory Approvals and Guidelines: As GLP-1 receptor agonists receive more regulatory approvals and are recommended in treatment guidelines for diabetes management, their adoption in clinical practice continues to grow, further solidifying their position in the market

That idea is an extrapolation from rat data

Developmental expression of receptors for insulin, insulin-like growth factor I (IGF-I), and IGF-II in rat skeletal muscle