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Researchers at Monash University recognized that many individuals seeking fat loss could not tolerate or did not need growth hormones broader effects including muscle growth, glucose elevation, and IGF-1 stimulation

Melanotan II, by contrast, is a cyclic analogue that activates all five MCR subtypes non-selectively, producing broader systemic effects alongside tanning

Current evidence suggests GLP-1s do not directly worsen IBD inflammation, yet individual responses vary significantly, making provider assessment critical before starting any peptide therapy

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