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For example, it affects (1) whether people participate in the treatment, (2) how likely they are to tell the people they care about, and (3) whether they allow themselves to keep using something long-term that is working
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Studies estimate 3040% of weight lost on GLP-1 medications can be muscle mass if no countermeasures are taken
Human trials of GLP-1 medications in women with PCOS have found (2): Ovulation rates of 86% in women taking GLP-1s alongside metformin - compared to 29% on metformin alone, a threefold improvement 62% of women on GLP-1s had more regular menstrual cycles, versus 28% on placebo Significant reductions in testosterone levels These are meaningful numbers for a condition where restoring ovulation and cycle regularity remains one of the challenges
The dual mechanism reduces glucagon levels and decreases hepatic glucose production, thereby aiding in the overall management of T2D (Nauck and DAlessio 2022
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