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In addition, administration of selected prebiotics or probiotics can improve metabolic alterations in animal models of metabolic liver disease [103],[127] and in obese human individuals [234],[235]
The single biggest variable in whether GLP-1 works long-term is protein
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This stepwise approach minimizes gastrointestinal side effects but means that full appetite-suppressing effects may not manifest until patients reach higher doses, often at 1.7 mg or 2.4 mg weekly for weight management indications
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