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Thiamine is integral to the biochemistry of the nervous system, serving primarily as a coenzyme in key enzymatic reactions associated with energy metabolism, particularly the conversion of carbohydrates into usable energy (5, 7, 29)
Its chemical structure allows researchers to study receptor-binding interactions in a controlled laboratory environment
Research so far shows that it impacts the Hypothalamic-Pituitary-Adrenal axis and lowers the production of stress hormones like cortisol and ACTH, perhaps precisely why it plays a part in restoring normal sleep
They enable rapid energy delivery by stimulating the immediate release of glucose into the blood stream
And as a consequence, markers of tissue inflammation also increase as we age because you're sort of removing this anti-inflammatory compound that's released each night
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