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Activation of GLP-1R induces an increase in intracellular Ca 2+ in 40% of NTS astrocytes, while selective inhibition of astrocyte function in NTS abolishes exendin-4-induced inhibition of food intake (Reiner et al., 2016)
Before discussing a switch or starting any incretin-based medicine, prepare the details that change risk and eligibility
it is not the same as proving it changes the outcomes patients actually care about
Proc Natl Acad Sci U S A 101:97749
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