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Duodenal switch bypasses even more
You get two doses plus a small remainder
Injectable B12 bypasses this entirely and achieves near-100% bioavailability
Oral administration to diet-induced-obese mice for ~10 days reduces fat mass without altering food intake, decreases adipocyte size, restores insulin sensitivity, and increases adipose NAD and SAM levels [2]
Some advocate prophylactic mesh placement, while others warn against it due to risks of infection and mesh erosion
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