glutathione and superoxide dismutase Peroxidase as biomarkers for endometriosis Re:Re: First line defence antioxidants-superoxide

What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect

144 Among them, P-gp/ABCB1, 145 MDR-associated proteins (MRPs/ABCCs), 146 and BCRP/ABCG2 147 are most extensively studied

So the grand scheme of the whole thing is not a bad thing

no human safety data exists and no formal pharmacokinetic study has been published in any species

Therapeutic doses of vitamin C have been shown to be toxic to cancer cells and are well-known for their effectiveness in building immunity