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Though, recently it has been pointed out that the molecular pathways controlled by these two transcription factors not only are highly overlapping, with Nrf2 able to modulate genes involved in lipid metabolism and LXR involved in the promotion of glutathione transferase, but they are also mutually interconnected 38,39,40
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Phase II trial shows that higher doses of up to 16 mg of the GLP-1 receptor agonist (RA) semaglutide improve glycaemia and induce weight loss at the cost of reduced tolerability
Moreover, Kyn pathway may critically influence glutamate neurotransmission [225]
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