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mTOR controls mitochondrial oxidative function through a YY1PGC-1 transcriptional complex
By the time Wegovy became reliably available, the public had absorbed Ozempic as the generic term for semaglutide weight loss even though Ozempic remains technically licensed only for type 2 diabetes
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The discovery of new lipolytic enzymes and coregulators, the demonstration that lipophagy and lysosomal lipolysis contribute to the degradation of cellular lipid stores and the characterization of numerous factors and signalling pathways that regulate lipid hydrolysis on transcriptional and post-transcriptional levels have revolutionized our understanding of lipolysis
Nature Medicine , 25 (5), 825837
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