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HSC70 recognizes the KFERQ-like motif in Substrate proteins, triggering their unfolding and Subsequent entry into the lysosome through the lysosomal-associated membrane protein 2 (LAMP2) membrane protein [21]
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(2017) CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2-ATF4 pathway, Oncotarget , 8 , 114588-114602, doi: Lei, P., Bai, T., and Sun, Y
However, the result is not the same for everyone, and the effect goes away when you stop the treatment
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