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The aims of the treatment of glutathione synthesis defects are to avoid hemolytic crises and to increase the defense against reactive oxygen species

Both components independently synthesised at 99%+ purity, precision-combined and co-lyophilised at Pinnacle Peptides USA facility

Although oral therapy with the least toxic of these compounds, glutathione monoethyl ester, did raise erythrocyte and white blood cell glutathione levels in a few affected patients (W Rhead, unpublished results), it also provoked moderate gastrointestinal irritation resulting in vomiting and diarrhea, largely precluding oral therapy with this compound or other related molecules containing free sulfhydryls

doi: 10.1186/s13024-024-00766-0 166 NiccolaiE.Di GloriaL.TroleseM

that is especially true of dried tangerine peel