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Advancing rhodium nanoparticle-based photodynamic cancer therapy: quantitative proteomics and in vivo assessment reveal mechanisms targeting tumor metabolism, progression and drug resistance

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Animal and tissue Adult male SD rats, weight 250300 g were purchased from National Laboratory Animal Center (Taipei, Taiwan, ROC)

In summary, tumor-specific receptor-targeted LYTACsincluding those engaging FR, GPC3, HER2, sortilin, and CAIXprovide a powerful and expanding set of nanomaterial platforms that confine lysosomal protein degradation to malignant tissue, thereby enhancing specificity and therapeutic index in cancer therapy

This action can remove old and unhealthy cells called senescent cells