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Injectable overdose is theoretically possible but would require dosages hundreds or thousands of times higher than research protocols

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The medication was effective but required reconstitution before each injection, which patients found inconvenient

Glutathione (GSH) is a powerful antioxidant that protects cells from damage caused by free radicals and oxidative stress

While they found better skin outcomes in participants who used hydroquinone cream (a common melasma intervention), they also concluded that topical silymarin was also effective and produced fewer side effects.28 Wrinkles A lack of skin moisture is one of the factors behind fine lines and wrinkles.29 According to a 2012 study published in the African Journal of Biotechnology , milk thistle extract, emulsified into a topical cream, may help combat wrinkle formation by boosting moisture retention and preventing transepidermal water loss.30 An important caveat to consider is that all of our top recommended milk thistles are oral supplements, and research on oral milk thistle for the above purposes is somewhat lacking