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3.1 Pharmacokinetic Interactions Several in vitro and in vivo studies on the bioavailability and metabolism of TAM and its metabolite 4-hydroxy-tamoxifen found that morin (Shin et al., 2008), silybin (Shin and hoi, 2009), myricetin (Piao et al., 2008), and quercetin (Shin et al., 2006) significantly changed the pharmacokinetics of oral TAM, resulting in reduced systemic clearance (CL/F)

Cell type prioritization was done using the Pertpy 76 implementation of Augur 42 , which uses a random forest classifier to assess how accurately the experimental condition of cells within a given cell type can be predicted based on their gene expression profiles

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