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Caloric restriction has also been shown to alter circulating amino acid profiles and protein turnover dynamics [86, 87], further influencing systemic metabolic regulation under conditions of reduced nutrient inflow

These effects appear to be mediated, at least in part, through the GLP-1/Sirtuin (SIRT1) pathway or via suppression of myostatin, while concomitantly reducing inflammation, thereby mitigating muscle wasting associated with SO [92,93,94]

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