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These medicines work by harnessing gut-brain hormonal pathways to reduce appetite and change food intake behaviour, a far more targeted approach than telling patients only to eat less and move more
J Cereb Blood Flow Metab 35(5):747750 Pienaar IS, Lee CH, Elson JL, McGuinness L, Gentleman SM, Kalaria RN et al (2015) Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinsons disease
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They lower glucagon, a hormone that increases blood sugar
This is materially unsustainable without an active management framework
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