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Acid reflux and GERD can develop or worsen over extended periods, and short-term studies may not fully reveal these trends

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The FDA-approved labeling for semaglutide and tirzepatide includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies

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First, although we initially planned to include five mice per group, one animal in the tirzepatide-treated group died just before drug administration (day 0), and an additional mouse died on day 10 after treatment initiation