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In Donor+Cas9 treated mice, these markers were comparable to those observed in mice fed with normal fat diet (Normal Diet) over 24 weeks, demonstrating a prolonged anti-diabetic effect from in vivo genome editing (Fig

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This research and subsequent call-to-action was part of a multi-disciplinary team effort across University of California, Irvine, and included the UCI School of Medicine, UCI School of Pharmacy and Pharmaceutical Science and the UCI Institute for Clinical and Translational Science.