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TRIUMPH-4 (Completed December 2025) Primary Endpoints: Weight loss (28.7% achieved) Knee osteoarthritis pain reduction (75.8% improvement) Secondary/Exploratory Endpoints (Liver): Liver enzymes (ALT, AST, GGT) Possibly liver imaging (ultrasound or MRI) in subset Not liver biopsies Expected Publication: 2026 (full results) What We'll Learn: Do liver enzymes normalize with 28.7% weight loss in larger population

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Accessed 23 Jun 2022