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NNC0165-1875 has recently completed a phase 2 trial in combination with semaglutide 2.4 mg once weekly (NCT04969939), but results are not currently available
A study at the University of Adelaide looking at ways to trigger release of the gut hormone GLP-1 - the hormone upon which weight-loss drugs are based - previously found that giving a bile acid enema to healthy volunteers triggered release of GLP-1, but had the unintended consequence of causing diarrhea
The result is decreased intestinal transit time and harder, less frequent stools
In clinical studies[7], the most common reactions included: Flushing Injection site reactions Headache Vomiting Blurred vision Joint pain or swelling Nasal congestion Cough Darkening of the skin on the face, gums, or breasts These effects can be uncomfortable, but theyre typically short-lived and manageable for most people
"REVERSING AGING: PREVENTING AGE-RELATED DECLINE IN GLUTATHIONE AND MITOCHONDRIAL FUNCTION INCREASES LONGEVITY." Innovation in Aging
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