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NPM1 mutations are known to result in aberrant cytoplasmic localization and downregulation of the NPM1 protein 28 , as observed in our data (log 2 fold change (FC): 0.44, P 0.2 for C3, C7 and C8)
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Importantly, the liver of OSKM mice does not exhibit histological changes after 7 days of doxycycline 9 , making the reduction in PCs unlikely to reflect liver dysfunction as a result of reprogramming
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