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The coming of age of chaperone-mediated autophagy
Laboratory investigations using ionizing radiation-induced senescent cells demonstrate that FOXO4-DRI causes p53 nuclear exclusion and mitochondrial targeting, validating the proposed mechanism of selective senescent cell elimination through targeted protein-protein interaction disruption
These antioxidants, while powerful defenders in their own right, become oxidized and lose their antioxidant capacity after neutralizing free radicals
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