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Such maladaptive neural plasticity could lead to abnormal patterns of autonomic and neuroendocrine acitivity.35,36 The fact that vomiting and retching during the emetic phase of CVS are mainly produced when the stomach is empty, implies that the allostatic feedback mechanisms are disordered, which could give rise to a reduced threshold for vomiting and retching, regardless of physiologic necessity or peripheral information

[23] The Werner (WRN) DNA helicase gene, which controls the transcription of the crucial NAD+ biosynthetic enzyme nicotinamide nucleotide adenylyltransferase 1, is the source of WS

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Acetic acid (0.1%) or dilute HCl Can be used sparingly for highly hydrophobic peptides