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Study eligibility criteria Inclusion criteria Investigated curcumin, curcumin analogs, or curcumin-based nanoformulations Reported outcomes in wound healing, anti-inflammatory, tissue repair, angiogenesis, or antioxidant effects in vitro, in vivo, or clinical studies Studies reporting mechanistic insights (e.g., NF-B, Nrf2/ARE, PI3K/Akt, TGF- pathways) Nanoformulation-based studies, including nanoparticles, nanofibers, hydrogels, liposomes, nanoemulsions, composite scaffolds/dressings Articles published in peer-reviewed journals Exclusion criteria Conference abstracts, non-peer-reviewed articles, and posters Research not focused on wound healing or lacking relevance to curcumins tissue-regenerative mechanisms Articles without extractable mechanistic or biological outcome data Duplicates, editorial pieces, or commentary papers Computational studies lacking experimental validation unless relevant to structure elucidation Outcome Chemical structures of heterocyclic curcumin analogues were accurately retrieved and cross-verified using PubChem, ensuring structural consistency

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Feldstein, E