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The simultaneous increase in NADP and decrease in NADPH act additively to increase G6PD activity by increasing the substrate drive on the reaction rate and decreasing product inhibition
In comparison, studies show that Mounjaro users lost 22.5% of their body weight on average after 72 weeks, and Wegovy users taking a 7.2mg dose lost up to 20.7% of their body weight after 72 weeks
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