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Semaglutide and liraglutide, two prominent GLP-1s, have been particularly effective in reducing cardiovascular events

And you could also see a situation where just as many of the complications of living with diabetes for years to decades could be caused by the insulin therapy, it's quite possible that over years or decades of the use of GLP1s, and the younger you are when you start the longer you'll have for this to happen could be caused by the drugs or exacerbated by the drugs

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Retatrutide itself has no direct effect on muscle protein synthesis or anabolic pathways