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A Bayesian hierarchical model was fitted using the brms framework, specifying percent weight change as a Gaussian outcome with (i) drug-specific smooth dose effects (splines by drug), (ii) treatment duration included as a covariate to account for variability in follow-up time across trials, and (iii) a study-level random intercept to account for between-trial heterogeneity

Conversely, valproate may displace certain protein-bound drugs (e.g., phenytoin, carbamazepine, warfarin, and tolbutamide) [seeDrug Interactions (7.2)for more detailed information on the pharmacokinetic interactions of valproate with other drugs ]

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