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For example, different actions of GLP-1 receptor agonists such as delaying gastric emptying which leads to a prolonged feeling of fullness and reducing food intake lead to significant weight loss ( Endogenous GLP-1 has a short half-life since it is in 1-2 minutes degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)
Not medical, dosing, or usage guidance
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In theory, delayed gastric emptying could modestly affect its absorption profile
Context from studies: clinical trials like SURPASS and SURMOUNT consistently reported gastrointestinal symptoms as the most common adverse events, and these are the primary reasons some participants discontinue therapy
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