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A 48-week Phase 2 trial reported in The Lancet in 2025 showed mean weight reduction ranging from approximately 9% at the lowest dose to 20% at the highest dose, compared with 0.4% on placebo
de Torres-Snchez, A
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The stigma is fading
For example, certain GLP1R variants may correlate with differences in baseline GLP-1 receptor signaling, but individual response also depends on dose, duration, lifestyle, and metabolic state
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