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The disulfide bonds are reversible, and they can again be reduced to thiol groups in proteins (e.g., protamine Cys residues) (152)

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Dose Range: 2001,000 mcg daily with gradual titration over 10 weeks

In a pre- and post-natal study in rats administered subcutaneous doses of 0.02, 0.10, or 0.25 mg/kg tirzepatide twice weekly from implantation through lactation, F 1 pups from F 0 maternal rats given 0.25 mg/kg tirzepatide had statistically significant lower mean body weight when compared to controls from post-natal day 7 through post-natal day 126 for males and post-natal day 56 for females