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Cureus 16, e72080
Increased fluid intake : Patients experiencing nausea or following dietary advice may increase water consumption, naturally leading to more frequent urination
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141,142 Adipocytes also produce apelin that is increased in insulin resistant individuals 143 and morbidly obese subjects with T2DM
Do not use retatrutide if you have: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis Severe gastroparesis or other serious GI motility disorders Known hypersensitivity to any component of the drug Use with caution and close monitoring if you have: Existing cardiovascular disease, given the heart rate increase Gallbladder disease or a history of gallstones Kidney disease, as dehydration from GI side effects can worsen kidney function Type 1 diabetes or insulin-dependent Type 2 diabetes A history of eating disorders, as extreme appetite suppression can interact with disordered eating patterns in unpredictable ways Pregnancy is an absolute contraindication
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