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Four structural regions were considered in our quest to improve GLP-1R agonist activity of small molecule 2 : the piperidine ring (yellow), the benzyl ether (green), the 5-fluoro-pyrimidine (blue), and the benzimidazole (red), as highlighted in Fig

Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, et al

These advances have earned Drucker a growing list of awards and accolades, including the Canada Gairdner International Award and a spot on Time magazines list of 100 most influential people

Hightower (Metabolon, Durham, NC) for assistance with metabolomics analyses and interpretation

doi: 10.1161/CIRCRESAHA.116.308999