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A 2021 review examining NNMT as a drug target explicitly notes that NNMT-inhibitor drugs remain limited in clinical use and that the field is still working out selectivity and delivery
the difference between AOD-9604 arms and placebo was not statistically significant at either point, and development was terminated
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It sends B12 straight into the blood, skipping the guts absorption hurdles
By inhibiting NNMT, 5-Amino-1MQ has been observed in models to elevate NAD+, activate downstream metabolic regulators, and support pathways that encourage higher energy expenditure and reduced adiposity
Often, B is given as a separate injection if needed
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