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13 Twincretins: Dual GLP-1 and GIP Receptor Agonists Research on incretin-based therapies for T2DM has seen an exponential increase in the past three decades

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Check fasting glucose daily Check pre-meal and 2-hour post-meal glucose at least once daily Record all hypoglycemia events (glucose below 70 mg/dL) If fasting glucose drops below 80 mg/dL on 2+ consecutive days, reduce basal insulin by another 10% If post-meal glucose is consistently below 120 mg/dL, reduce bolus insulin by another 10 to 20% Step 4: Semaglutide dose escalation adjustments (every 4 weeks)

Foundayo (Orforglipron) As a newly FDA-approved medication, Foundayo constitutes an exciting daily oral option with maximum dosing flexibility