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When to Contact Your Provider Contact your prescribing provider if a nodule is warm to the touch, red, expanding rather than shrinking over 48 hours, or accompanied by fever

The SURMOUNT-1 trial (N=2,539), published in the New England Journal of Medicine in 2022 (DOI: 10.1056/NEJMoa2206038), evaluated tirzepatide at 5mg, 10mg, and 15mg weekly doses versus placebo in adults with obesity or overweight

These reactions can manifest as: While some such injection site reactions may be mild and short-lived, others are more severe and require medical attention

This is why vial size planning matters

Human safety data on long continuous use is limited, so capping exposure is reasonable caution