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This dual activation is why tirzepatide outperforms semaglutide for appetite suppression

For Maximum Weight Loss: Tirzepatide (22.5% average loss) Semaglutide (14.9% average loss) Distant third: Phentermine-topiramate (9.3% loss) For Best Value: Compounded semaglutide ($97 per pound lost) Compounded tirzepatide ($112 per pound lost) Others significantly worse For Most Patients: Compounded semaglutide or compounded tirzepatide provide the best combination of effectiveness, tolerability, and affordability

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