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PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)
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Evidence for complete B cell differentiation of a subpopulation of DNA aneuploid leukemic cells in Non B, Non T acute lymphoblastic leukemia (ALL)
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