FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells
In contrast, tellurium-containing nanomicelles form stronger platinummetal bonds due to Tes higher metal affinity, enabling slower, sustained cisplatin release that prolongs therapeutic effects while minimizing systemic toxicity
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In the same study, Dato-DXd also achieved and ORR of 35% and DoR of 9.5 months in 34 NSCLC previously treated patients with actionable genomic alterations, including anaplastic lymphoma kinase ( ALK ) (n=3), epidermal growth factor receptor ( EGFR ) (n=29), ROS (n=1), and RET (n=1) [43]
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