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More importantly, the expansion of water as it freezes can compromise the vials seal or even cause micro-fractures, destroying its sterility
Medial Collateral Ligament Healing Cerovecki et al
This can be problematic for people with certain health conditions or older adults whose digestive efficiency may be compromised
That is why 5 mg in 1 mL reads as half the units of 5 mg in 2 mL for the same dose
Wilding JPH, et al
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