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In PCOS specifically, where excess adiposity and hepatic steatosis are common amplifiers of an already-present insulin-resistant state, this route alone would be expected to lower hyperinsulinemia and, by extension, reduce the insulin drive to ovarian androgen synthesis
Third, the study only included patients whose dose was escalated to 1.0 mg and lacked a control group of patients who maintained the 0.5-mg dose
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While beneficial for patients with obesity and metabolic syndrome, unintended weight loss can be detrimental in Crohn's disease patients who already struggle with malnutrition, malabsorption, or disease-related cachexia
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