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Enhanced Weight and Metabolic Parameters: Mean body weight reductions of 510 % are accompanied by improved fasting glucose, insulin, and lipid profiles
Megens RTA, Vijayan S, Lievens D, Dring Y, van Zandvoort MAMJ, Grommes J, et al
In conclusion, preclinical and emerging clinical evidence are changing the paradigm, viewing incretin receptor agonists solely as metabolic-based therapeutics for treating obesity and diabetes to recognising them as multifaceted agents with significant disease-modifying potential for inflammatory fibrotic disorders across different organ systems
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Surprisingly, given the limited amount of training data, we found that an ensemble of multi-task convolutional neural-network (CNN) models that simultaneously predict potency at both GCGR and GLP-1R provides significantly better performance against GLP-1R, whereas performance differences against GCGR were largely not significant
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