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A more prudent strategy involves limiting necroptosis inhibition to the early phase of AECOPD, primarily driven by viral infection or severe oxidative stress, with short-term combined anti-infection and anti-inflammatory treatment to alleviate inflammation and structural damage while avoiding excessive suppression of long-term immune surveillance and host defense (83, 84) ( Figure 3 )
This dual-pathway angiogenic effect provides more comprehensive vascular support to healing tissue than either compound can deliver alone
Researchers have also observed that glutathione regulates protein function through reversible S-glutathionylation of cysteine residues, modulating the activity of signaling proteins, transcription factors, and metabolic enzymes in response to oxidative conditions
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