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Dr Lamberti has no conflicts of interest related to the subject of this article
10.1016/j.mce.2016.08.005 Summary Keywords estrogen, testosterone, granulosa cells, theca cells, Sertoli cells, Leydig cells, signaling Citation Ipsa E, Cruzat VF, Kagize JN, Yovich JL and Keane KN (2019) Growth Hormone and Insulin-Like Growth Factor Action in Reproductive Tissues
That includes metabolic labs and assessment of any history of pancreatitis, thyroid disease, or other contraindications
Although previous studies showed a lack of therapeutic benefit for GIP agonists, current studies show that the glucose lowering and weight loss effects of tirzepatide are at least as effective as GLP-1 RAs with a similar adverse effect profile
Its safety profile is similar to existing incretin-based therapies, making it a particularly promising candidate for obesity, type 2 diabetes, and related metabolic conditions
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