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Conclusion GLP-1 is a multifaceted hormone with significant implications for glucose metabolism, insulin secretion, and appetite regulation

For context, diarrhoea is reported in approximately 916% of patients taking semaglutide 2.4 mg (Wegovy) according to its UK Summary of Product Characteristics (SmPC, emc), and in a broadly similar range for tirzepatide (Mounjaro) per its UK SmPC

Semaglutide slows stomach emptying and increases sensitivity to gastric irritation, while alcohol directly irritates the stomach lining and impairs normal digestive function

2.2 Glucose tolerance tests and AUC measurements Blood glucose was monitored by examining tail vein blood using the Roche blood glucose monitoring system

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