Evidence links GLP-1 receptor agonists to lower dementia risk and reduced neuroinflammation, supporting continued study, especially earlier in disease progression
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As companion supplements, yes, the core list earns its place: protein and resistance training to protect muscle, fiber for constipation, fluids and electrolytes for hydration, and targeted vitamins like B12 when blood work shows a gap
However, when it was reported that GLP-1 was a substrate for DPP-4 in pharmacological in vitro kinetic studies (18), this was quickly followed by the demonstration that the metabolite generated by DPP-4 cleavage was the major circulating component of GLP-1-like immunoreactivity in healthy individuals (19) and that the same metabolite formed rapidly following exogenous administration of GLP-1 in both healthy subjects and those with T2DM (20)
For a detailed breakdown of route-specific mechanisms, absorption differences, and use-case matching, see GHK-Cu Topical vs Injectable: Route Comparison