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Mutant IDH1 leads to the accumulation of the metabolite 2-hydroxyglutarate (2-HG), which stabilizes HIF-1, further promoting immune suppression in the TME
PMID: 19 PablosMIChuangJReiterRJOrtizGGDanielsWMSewerynekEet al
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iv Unfortunately, because acetaminophen is inexpensive and easy to purchase, it has become the most frequently chosen drug for attempted suicide among adolescents
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