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Less oversight could mean that there is more room for error
It activates the same receptors your bodys natural GLP-1 uses to signal fullness, while also activating GIP receptors involved in fat metabolism
Metformin also has modest effects on weight, typically resulting in small reductions or weight stabilisation rather than significant loss
However, in certain cases, they may interfere with the peptides ability to interact with its target or disrupt bioactive conformation, significantly reducing its activity 44,45
After propensity-score matching, the two cohorts (504 in each cohort, mean age 46.1 years, 57.5% women, 26.4% black, 54.7% white, 6.7% Hispanic) were balanced (see Supplementary Table S2 in the Supplementary Appendix)
