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Beta blockers can be taken concurrently with retatrutide, but they may not fully control the heart rate increase because retatrutide works through the glucagon receptor cAMP-PKA pathway rather than the sympathetic nervous system that beta blockers target

The primary analysis for the trial product estimand was carried out using a mixed model for repeated measurements using a restricted maximum likelihood, with treatment and region as categorical fixed effects and baseline HbA 1c or body weight (depending on the analysis) as covariate

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